So Simple a Beginning: How Four Physical Principles Shape Our Living World

So Simple a Beginning: How Four Physical Principles Shape Our Living World

by Raghuveer Parthasarathy
So Simple a Beginning: How Four Physical Principles Shape Our Living World

So Simple a Beginning: How Four Physical Principles Shape Our Living World

by Raghuveer Parthasarathy

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Overview

A biophysicist reveals the hidden unity behind nature’s breathtaking complexity

The form and function of a sprinting cheetah are quite unlike those of a rooted tree. A human being is very different from a bacterium or a zebra. The living world is a realm of dazzling variety, yet a shared set of physical principles shapes the forms and behaviors of every creature in it. So Simple a Beginning shows how the emerging new science of biophysics is transforming our understanding of life on Earth and enabling potentially lifesaving but controversial technologies such as gene editing, artificial organ growth, and ecosystem engineering.

Raghuveer Parthasarathy explains how four basic principles—self-assembly, regulatory circuits, predictable randomness, and scaling—shape the machinery of life on scales ranging from microscopic molecules to gigantic elephants. He describes how biophysics is helping to unlock the secrets of a host of natural phenomena, such as how your limbs know to form at the proper places, and why humans need lungs but ants do not. Parthasarathy explores how the cutting-edge biotechnologies of tomorrow could enable us to alter living things in ways both subtle and profound.

Featuring dozens of original watercolors and drawings by the author, this sweeping tour of biophysics offers astonishing new perspectives on how the wonders of life can arise from so simple a beginning.


Product Details

ISBN-13: 9780691258676
Publisher: Princeton University Press
Publication date: 03/19/2024
Pages: 336
Sales rank: 258,051
Product dimensions: 5.70(w) x 8.80(h) x 1.00(d)

About the Author

Raghuveer Parthasarathy is an Alec and Kay Keith Professor of Physics at the University of Oregon, where he is a member of the Institute of Molecular Biology and the Materials Science Institute. He lives in Eugene, Oregon. Website eighteenthelephant.com Twitter @RParthasarathy7

Table of Contents

Introduction 1

Part I The Ingredients of Life

1 DNA: A Code and a Cord 15

2 Proteins: Molecular Origami 29

3 Genes and the Mechanics of DNA 44

4 The Choreography of Genes 60

5 Membranes: A Liquid Skin 75

6 Predictable Randomness 90

Part II Living Large

7 Assembling Embryos 105

8 Organs by Design 124

9 The Ecosystem inside You 134

10 A Sense of Scale 155

11 Life at the Surface 173

12 Mysteries of Size and Shape 183

Part III Organisms by Design

13 How We Read DNA 199

14 Genetic Combinations 220

15 How We Write DNA 239

16 Designing the Future 260

Acknowledgments 277

References 279

Index 317

What People are Saying About This

From the Publisher

“Deft and engaging. Parthasarathy constantly finds the metaphors that best illuminate his subject. And what a subject—a perfect mix of the latest exciting new work with classic results needed to understand it. Every chapter gives an original view from a wide-ranging intellect, and unifies ideas that are rarely presented together.”—Philip Nelson, author of From Photon to Neuron: Light, Imaging, Vision

“Parthasarathy presents an accessible yet scientifically accurate picture of modern biology, and it’s a pleasure to read.”—Sonia Contera, author of Nano Comes to Life

“Parthasarathy has given readers a delightful narrative guide to the exciting and important ways in which physics and biology come together to help us understand living matter. I found myself learning something new in every chapter and loved the fun case studies, constant insights, and captivating illustrations.”—Rob Phillips, author of The Molecular Switch: Signaling and Allostery

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